FeatureNix/DevBoxDocker
Isolation levelPackage-levelContainer-level
Resource usageGenerally more efficientPotential for higher disk usage
ReproducibilityPackage-level reproducibilityImage-level reproducibility
Host integrationTighter integrationMore isolated
Learning curveSteeper (especially Nix)Generally easier to start
FlexibilityFine-grained package controlWhole environment isolation
PerformanceSlightly better (less overhead)Small virtualization overhead
Updates/rollbacksAtomic at package levelTypically whole image updates
EcosystemSmaller, growingLarge, well-established
Multi-versionNative supportPossible but less straightforward
ConfigurationDeclarative (Nix lang)Dockerfile and compose files